Italy coach Roberto Mancini is "very sorry" Cristiano Ronaldo will not be involved when Portugal visit San Siro in the Nations League on Saturday.
Ronaldo has not featured for his country since the World Cup, with coach Fernando Santos and the country's Football Federation affording him a break.
It remains unclear as to when Juventus star Ronaldo will return to action for Portugal and he is unlikely to feature before March, though his self-imposed exile could continue later into 2019.
Nevertheless, the European champions have prospered in Ronaldo's absence, recording three wins and a draw in the four matches they have played since an underwhelming last-16 World Cup exit to Uruguay.
They go into the game with Italy top of League A Group 3, though the focus still remains on their absent talisman.
"Cristiano is one of the best players in the world," Mancini told reporters at his pre-match news conference. "For sure with him on the pitch it would be a different game because he has unique skills.
"But Portugal have other extraordinary players in the offensive phase. I believe it will be a spectacular game even without Cristiano Ronaldo, though we would have liked to face him.
"I think with him on the pitch it would have been even more spectacular. We are very sorry he is not playing tomorrow [Saturday]."
Nevertheless, Italy defender Giorgio Chiellini - who lines up at Juventus alongside Ronaldo - insists the Azzurri will not be altering their outlook, adamant Portugal have plenty of other weapons in their arsenal.
"For us, it [Ronaldo's absence] won't change anything in terms of our approach," the centre-back added.
"It's clear that Cristiano Ronaldo would be decisive for any team. He is the best player in the world and therefore you cannot say Portugal are the same team without him.
"But Portugal is a good team and they showed they can play and win games even without Cristiano Ronaldo.
"In the Euro 2016 final, even though he was missing, they beat France. They are a very good team and it won't be easy for us."
|Klopp: I´m not the pope of football tactics|
|Stade beat Ospreys on emotional Chauvin tribute night|
|Ligue 1 survival bid a marathon not a sprint for Monaco, as club appoints distance runner|
|Vertonghen eyeing Spurs future beyond 2020|
|De Bruyne injuries could be a blessing for City, says Guardiola|
|Emery prepared to face Arsenal´s centre-back crisis|
|Ulster complete Scarlets double, Exeter gain Gloucester revenge|
|Sheffield United 1 West Brom 2: Baggies comeback boosts automatic promotion push|
|Del Potro back on court following knee injury|
|Canelo v Fielding: Rocky ready to write his own fairytale in New York|
|Boca part company with Schelotto after Copa Libertadores loss to River|
|Canelo v Fielding: Tale of the tape|
|Juventus defender Cancelo has knee surgery|
|Canelo v Fielding: Alvarez and Rocky make weight in New York|
|Spalletti does not fear another mid-season crisis at Inter|
|Salah headlines CAF Player of the Year shortlist as Koulibaly misses out|
|Beckham Jr. out of Titans clash|
|Lipsky hits the front at Leopard Creek|
|Pederson coy over Wentz back injury|
|Liverpool ´not really likely´ to be active in January window, reveals Klopp|
|Always on the move and unpredictable - Pavard reveals surprising choice over toughest opponent|
|We need to get back to respect - Lampard alarmed by hate in football|
|Giles returns to England to replace Strauss as director|
|Hansen has no issue with Milner-Skudder Toulon switch|
|Juventus to rest Ronaldo after Torino showdown|
|Titmus strikes gold again as world records tumble in Hangzhou|
|Malinga to captain Sri Lanka in New Zealand|
|Rivaldo would like ´excellent´ Isco at Barcelona|
|United a long way from Mourinho´s vision|
|´Klopp denies an answer!´ - Liverpool boss dismisses questions about ´world-class´ Pogba|
|Returning Nowitzki ´so tired´ after making NBA history|
|Aguero and De Bruyne in contention for Manchester City v Everton|
|Simeone has no plans to cash in on Costa|
|Canelo v Fielding: Alvarez´s greatest nights|
|Fabregas: Chelsea being unfairly scapegoated over racism allegations|
|Crisis? What crisis? Klopp focuses on defensive solutions for United clash|
|Hope cannot inspire Windies as Bangladesh cruise to series win|
|Benitez picks up Premier League Manager of the Month award|
|Chavez, Marquez and Canelo - Mexico´s greatest multi-weight world champions|
|Bale set to miss Real Madrid v Rayo Vallecano|
|Robben out until January as Bayern look to avoid serious injury|
|Milan avoid UEFA ban in FFP punishments.|
|Mourinho compares Liverpool to ´an amazing house´ but insists trophies matter|
|Brisbane Roar 2 Melbourne Victory 4: Muscat´s men hit A-League summit|
|Bumrah confident second Test is ´in the balance´ after India recovery|
|Isco gesture was for a corner or foul, claims Solari|
|Harris leads Australia into ascendancy on day one|
|ATP announces candidates to host future Finals|
|Ronaldo: Juventus fans refuse to lose to Torino|
|Hero Rivers feared he had cost Chargers in KC|
|Williams would welcome Llorente back to Athletic Bilbao|
|Liverpool v Manchester United: Minding the gap|
|Milan elimination unjust, fumes Leonardo|
|Paul hails ´sick´ Harden after record-breaking display|
|Liverpool v Manchester United: Salah, Mane and Firmino v Rashford, Martial and Lukaku in Opta number|
|Canelo open to GGG trilogy as he chases place in Mexican history|
|The big Friday Premier League quiz|
|Harden posts record fourth 50-point triple-double in win over Lakers|
|Barcelona squad happy with Dembele, says Alba|
|Chargers rally past Chiefs to clinch playoff spot|
|WATCH: Chargers top Chiefs on dramatic two-point conversion in final seconds|
|Suns owner Sarver committed to keeping team in Phoenix|
|Chargers WR Allen leaves with injury after near-spectacular catch|
|Socceroos not giving up on Mooy for Asian Cup|
|Cooper says Raiders owner wanted to trade him to Cowboys|
|Pochettino jokes Levy is ´worried´ about losing him|
|Barcelona would welcome Morata – Alba|
|Toure not a priority for West Ham – Pellegrini|
|Koscielny no certainty to face Southampton, says Emery|
|We gifted the game – AC Milan boss Gattuso furious after Europa League exit|