Toby Alderweireld will not be ready to make his Tottenham comeback until February, while manager Mauricio Pochettino has confirmed there has been no progress on the defender's contract talks.
Alderweireld injured a hamstring on November 1 in the Champions League defeat of Real Madrid at Wembley and has not played since.
The Belgian has been linked with a move to clubs including Chelsea, with his deal set to expire at the end of next season, but Pochettino shrugged off the 28-year-old being 18 months away from becoming a free agent.
"Of course we cannot change the reality of his injury, he cannot play until February," said Pochettino, whose side face Brighton and Hove Albion on Wednesday.
"With him or without him we win and lose. Of course the manager always wants all the players to be fit to play like [Victor] Wanyama, Danny Rose or [Erik] Lamela before.
"Always you are going to miss the players that are not fit but that is normal. But for me football is about the team, it is not about individual players.
"Of course some players have more influence on the team but I think we have a good enough squad and players that can play, and win or lose it is about the quality of performance if we miss one or another player."
Of Alderweireld's contract, Pochettino added: "Of course it is his decision, it's our decision, he still has two years on his contract, and we are looking forward to him playing and to him staying here.
"The players are showing their commitment. I am so calm how [chairman] Daniel Levy drives everything and manages the contracts of the players and yes I am not worried or concerned about this."
While Alderweireld remains some time away from returning to action, Lamela is in line to make his first Premier League start since October 2016 against Brighton.
"Maybe, maybe [Lamela will start]," said Pochettino. "I still haven't decided. He has a chance to play from the start."
Spurs topped Group H ahead of Real Madrid and Borussia Dortmund, earning a last-16 Champions League meeting with Serie A winners Juventus, and Pochettino expects his side to face a tough test in February.
"I think it’s of course not an easy opponent in the Champions League at this stage, but we are so excited to play against Juventus," said Pochettino.
"Juventus are a great team, the best team in Italy. Of course, always in recent years they have been involved in semi-finals or finals. To have the possibility to play against them is so exciting for us, our fans and everyone. It will be very tough because they have a very good team."
|Leicester City 0 Southampton 0: Saints´ survival bid suffers fresh blow|
|Burnley 1 Chelsea 2: Conte´s men boost top-four chances with FA Cup warm-up|
|Fenerbahce-Besiktas abandoned after Gunes struck by object thrown from crowd|
|Quiros´ birdie-birdie finish earns a share of Rabat lead|
|New York Giants release Brandon Marshall|
|Real Sociedad 3 Atletico Madrid 0: Barca´s title party set to start|
|Thiem ready to up level for ´ultimate challenge´ of Nadal|
|Carrick reveals depression led to England exile|
|´Who are they?!´ - Accrington milk promotion with supermarket stunt|
|Mouthwatering Nadal-Djokovic quarter-final scuppered by Thiem|
|Stunning Gayle century ends Sunrisers´ unbeaten start|
|Conte names Hazard on bench for Burnley clash|
|Rooney denies rift with Everton boss Allardyce|
|Kane will leave Tottenham unless they win trophies, predicts Souness|
|Porzingis could miss 2018-19 season, Knicks owner says|
|Portugal´s Sanches has no chance of World Cup selection - Carvalhal|
|Spurs coach Popovich to miss game three after death of wife|
|Nadal reaches 14th straight Monte Carlo quarter-final|
|Better with one arm - Julio Cesar reveals Mourinho´s Casillas jibe|
|New Hamilton deal ´agreed in principle´ for Mercedes|
|Joseph likely to miss England´s tour of South Africa|
|Mourinho has nothing to prove - Pochettino|
|Bhatti pens one-year Glasgow extension|
|I have spoken to the chairman - Allardyce upset by Everton survey|
|Kit cat: Bath player offers signed shirt for missing pet|
|Emery dismisses talk of Real Sociedad offer|
|Thiem rallies to send Djokovic packing in Monte Carlo|
|Sidibe´s Monaco season over but World Cup return possible|
|Guardiola thanks ´unique´ City staff in celebration speech|
|Wan-Bissaka signs long-term Crystal Palace extension|
|Love will be ready for game three, assures Cavs coach Lue|
|Injured Raonic withdraws from Monte Carlo, Cilic advances|
|ECB announces 100-ball format for new domestic competition|
|Bottas aiming to overthrow Hamilton and claim world title|
|Rakitic to make comeback following finger surgery|
|FIFA dismisses Brewster racism complaint from U-17 World Cup final|
|Isak could benefit from Batshuayi injury - Stoger|
|Mitchell on target again in scrappy Roosters win|
|Shaw hopes to have earned FA Cup start|
|Mercado: If I smack Messi, I can´t go back to Argentina!|
|Salah wants Golden Boot to prove Chelsea doubters wrong|
|Chelsea´s Alonso gets three-game ban for Long challenge|
|Atletico clash absolutely vital to Arsenal´s season, admits Wenger|
|CSA wants interim agreement amid negotiations with South Africa players|
|Wenger still confident Wilshere will sign new deal|
|Read and Coles doubts for New Zealand´s France series|
|Paine vows to dial down Australia sledging|
|LeBron James denies he was blindsided by question on Popovich´s wife|
|Guardiola a friend as well as a boss, says Walker|
|Heaton: Europe a realistic possibility for Burnley|
|Late charge for the Golden Boot! - Smalling jokes about goalscoring form|
|Grand slams, walk-off hits highlight Blue Jays and Red Sox wins|
|Emery unsure when PSG star Neymar will return|
|Broncos boss Bennett walks out on press conference amid Bellamy speculation|
|Chiefs, Rams to play in Mexico City on November 19|
|LeBron James helps Cavs even series, Rockets rout T-Wolves|
|Marcelo backs Ronaldo to extend scoring run for Madrid|
|Copa Libertadores Review: Libertad preserve 100 per cent record, Corinthians stay unbeaten|
|Man United should have 10 more points – Mourinho laments inconsistency|
|Gombau sacked by Western Sydney Wanderers|
|Wife of San Antonio Spurs coach Gregg Popovich dies|
|Rafael: Van Gaal told me I could leave United after one-minute meeting|
|Klopp told Liverpool they could train naked because of Salah|
|Jazz star Mitchell to play game two against Thunder|
|Twins place Byron Buxton on 10-day DL with migraines|
|Zidane denies Bale problems, defends Benzema|
|Sarri: Napoli won´t change approach against Serie A rivals Juve|
|PSG will respect Les Herbiers, assures Emery|
|Chelsea boss Conte: It´s easier for Dyche at Burnley|
|It will be a great game - Allegri prepared for title showdown with Napoli|